Figure 1.

Brain-lesion studies of real tool use. Maximum lesion overlap locations are represented on the PALS-B12 left hemisphere (flat map, main figure; very inflated map, mini figure) atlas surface configuration.²⁴⁹ Brain areas are identified using anatomical labels from the parcellation of Glasser et al.⁸¹ Only the brain areas that have been reported in at least 50% of the conditions included here are represented (see Supplementary Methods). The main findings obtained by two neuroimaging meta-analyses on tool-use action understanding¹¹¹ and tool-use action observation¹¹⁴ are also shown.