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. 2022 Mar 9;18(3):e1010085. doi: 10.1371/journal.pgen.1010085

Fig 7. Model of how Set2 methylation may promote TC-NER of the TS and suppress cryptic TC-NER of the NTS.

Fig 7

During normal Pol II elongation (top panel), co-transcriptional H3K36me by Set2 suppresses cryptic antisense transcription, thereby preventing cryptic TC-NER of the non-transcribed strand (NTS). When Pol II stalls at a CPD lesion (bottom panel), Set2-catalyzed H3K36me may accumulate immediately behind the stalled Pol II, thereby serving as an epigenetic signal of Pol II stalling. Hyper-accumulation of H3K36me may promote TC-NER of the transcribed strand (TS) by recruiting Rad26 behind the stalled Pol II.