Table 3.
Parameters of responses of NI neurons to the MS optogenetic stimulation
| Response type | Fraction (count) | FR change (%) | Latency to maximum (ms) | Duration (ms) | |||
|---|---|---|---|---|---|---|---|
| Cortical activation | Tph-locked | Bursting (n = 7) | Inhibitory | 86% (6) | −45 (−53; −41) | 42.5 (35; 85.3) | 120 (107; 151.5) |
| Excited | 0% | ||||||
| No response | 14% (1) | ||||||
| Nonbursting (n = 5) | Inhibitory | 40% (2) | −65 | 57 | 142.5 | ||
| Excited | 40% (2) | 76 | 46 | 104.5 | |||
| No response | 20% (1) | ||||||
| Tph-indep. | Irregular (n = 16) | Inhibitory | 31% (5) | −58 (−71; −25) | 68 (34.5; 91) | 131 (87.5; 188) | |
| Excited | 25% (4) | 63 (43; 99) | 51.5 (47.8; 102.5) | 154 (99.8; 273.5) | |||
| No response | 44% (7) | ||||||
| Regular (n = 16) | Inhibitory | 25% (4) | −12 (−32; −5) | 38.5 (25.3; 51.8) | 126 (106.8; 139.3) | ||
| Excited | 19% (3) | 25 (11; 33) | 29 (23; 46) | 118 (103; 123) | |||
| No response | 56% (9) | ||||||
| Cortical SWA | Dw-locked | Bursting (n = 4) | Inhibitory | 75% (3) | −74 (−74; −54) | 92 (48; 109) | 132 (110; 140) |
| Excited | 25% (1) | 74 | 63 | 128 | |||
| No response | 0% | ||||||
| Nonbursting (n = 4) | Inhibitory | 0% | |||||
| Excited | 50% (2) | 77 | 40.5 | 173 | |||
| No response | 50% (2) | ||||||
| Dw-indep. | Irregular (n = 20) | Inhibitory | 25% (5) | −63 (−75; −33) | 46 (38; 56) | 108 (105.5; 125.5) | |
| Excited | 15% (3) | 104 (102; 106) | 54 (36; 123) | 121 (103; 294) | |||
| No response | 60% (12) | ||||||
| Regular (n = 9) | Inhibitory | 44% (4) | −17 (−20; −7) | 48 (30.8; 63) | 128 (79.3; 162.5) | ||
| Excited | 11% (1) | 14 | 30 | 122 | |||
| No response | 45% (4) |
Tph, Theta phase; indep., independent; Dw, delta wave; FR, firing rate.