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. 2022 Mar 7;13:817596. doi: 10.3389/fphar.2022.817596

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Copyright © 2022 Yuan, Hu, Liu, Xie, Yang, Li, Zhang, Chen, Tang and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oral administration of dehydrocostus lactone attenuates symptoms of DSS-induced colitis in mice. (A) Structure of DCL. (B) Schematic diagram illustrating the experimental procedure. The effects of DCL on body weights (C) in DSS-exposed mice. (D) Representative photograph of the appearance around crissum of mice from normal, DSS, and DCL-H groups, respectively. Representative photograph of the colon (E) and the statistics of colon length (F) in each group. The effects of DCL on spleen index (G) in DSS-exposed mice. Representative images of HE staining (H) and respective histopathological scores (I) of colon tissues in each group. Scale bar = 100 or 20 μm. Data are represented as mean ± SEM, n = 7. ^# p < 0.05, ^## p < 0.01, ^### p < 0.001, ^#### p < 0.0001 compared to normal group. ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001 compared to DSS group.