TABLE 2.
Subjects | Mean (SD)a
|
|||
---|---|---|---|---|
AUC (mg · h/liter) | CL (liter/h) | Vβ (liters) | t1/2β | |
Study patients | 277.31 (138.98)b | 9.06 (4.79) | 56.91 (25.93)* | 4.75 (1.85)* |
Historical controlsd | 153.5 (23.1)c | 6.64 (0.97) | 13.6 (1.9)* | 1.8 (0.14)* |
*, P < 0.001 by the unpaired t test.
AUCSS.
AUC from 0 h to infinity after a 1-g i.v. dose.
Data for controls are from reference 27.