Convergence in the major biological processes. Anticipating the predominant role of biological processes involved in hypoxia response, e.g., circulatory system (GO: 0003013), angiogenesis (GO: 0001525), erythrocyte homeostasis (GO: 0034101), and O2 transport (GO: 0015671), the HA selected genes involved in these specific GO classes were picked for network analysis from Gene Ontology Consortium (geneontology.org). The Venn diagram (except “oxygen transport” (GO: 0005344) because there were only 13 genes in this GO category and 5 were common) depicts the common gene(s) shared between HA candidate genes and the respective GO category’s gene list. The probability of gene enrichment at HA for these GO categories was significant (Fisher’s exact test P < 0.001). We used Genemania v3.4.1 app on Cytospace v3.4.0. Each network is restricted to Homo sapiens with weighting process only related to GO biological process-based