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. 2022 Mar 7;13:829712. doi: 10.3389/fphar.2022.829712

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Copyright © 2022 Fan, Lin, Huang, Xia, Xu, Zhang and Pi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different ways to enhance the antibacterial effect of the PDA nanosystem. (A) DNAse I can be used to destroy cell membrane densification for enhanced antibacterial effects, taking the thermosensitive CO gas releasing donor (FeCO)-encapsulated MPDA NPs with covalently fixed deoxyribonuclease I (DNase-CO @MPDA NPs) as an example (Yuan et al., 2021). (B) Inhibition of heat shock protein accumulation to enhance antibacterial effects, taking the PDA-encapsulated Fe₃O₄ and 2-phenylethyl sulfonamide (PDA@Fe₃O₄+PES) as an example (Liu et al., 2016).