TABLE 2.
Combinations of two or three antibiotics
| Combination
|
FIC index | Result | ||
|---|---|---|---|---|
| Antibiotic 1 (concn)a | Antibiotic 2 (concn)a | Antibiotic 3 (concn)a | ||
| Rifampin (1/4) | Azithromycin (1/4) | 0.5 | Synergistic | |
| Rifampin (1/2) | Ofloxacin (1/2) | 1.0 | Not synergistic | |
| Rifampin (1/2) | Doxycycline (1/2) | 1.0 | Not synergistic | |
| Azithromycin (1/4) | Ofloxacin (1/8) | 0.375 | Synergistic | |
| Azithromycin (1/4) | Doxycycline (1/4) | 0.5 | Synergistic | |
| Ofloxacin (1/2) | Doxycycline (1/2) | 1.0 | Not synergistic | |
| Rifampin (1/8) | Azithromycin (1/8) | Ofloxacin (1/8) | 0.375 | Synergistic |
| Rifampin (1/8) | Azithromycin (1/8) | Doxycycline (1/8) | 0.375 | Synergistic |
a
Concentration necessary to prevent C. pneumoniae inclusions, expressed as a fraction of the MIC.