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. 2022 Mar 21;11:e74011. doi: 10.7554/eLife.74011

Figure 4. Results of resting-state intrinsic connectivity.

Figure 4.

Analyses examining the functional architecture of DMN regions associated with reading and autobiographical memory (AM) retrieval and their relation to individual differences in naturally occurring mind-wandering during reading. Panel (A) shows the results of a functional connectivity analysis examining differences between the DMN seeds (reading DMN MNI coordinates: − 56,–10, –12; autobiographical memory DMN MNI coordinates: − 6,–50, 22). Regions showing stronger intrinsic connectivity to the reading DMN seed are shown in warmer colours, while regions showing stronger intrinsic connectivity to the autobiographical memory DMN seed are shown in cooler colours. The lower panel (B) shows results of a formal conjunction between regions associated with greater activity during reading versus autobiographical memory retrieval, and regions showing stronger correlation at rest with DMN seed activated by reading. Panel (C) shows the relationship of these seeds’ functional architecture and self-reports of mind-wandering during reading. Group-level regression, using the DMN site showing peak activation during reading as a seed, demonstrated stronger connectivity with regions in primary visual cortex and postcentral gyrus in individuals with good comprehension and less reported mind-wandering content. To visualise this effect, the scatterplots present the correlation between behaviour and the correlation between the reading-relevant DMN seed and the identified visual clusters (beta values). The error lines on the scatterplots indicate the 95% confidence estimates of the mean. Each point describes an individual participant. The word cloud shows the functional associations with this connectivity map identified using Neurosynth. (The unthresholded functional connectivity maps contrasting reading and autobiographical memory DMN seeds from (A), the conjunction map in (B), and the mind-wandering individual difference map in (C), used for Neurosynth decoding, are provided in Neurovault at https://neurovault.org/collections/9432/).