Figure 2.

RV infection and SPT deficiency induce similar changes in lung epithelial gene expression for sphingolipid synthesis. Gene ontology enrichment analysis of differentially expressed genes within the sphingolipid synthesis pathway (GO:0030148) for (A) lung, (B) lung EpCAM⁺ cells, and (C) lung CD45⁺ cells. Shown are results of hierarchical clustering of differentially expressed genes of Co + RV, SPT, and SPT + RV versus Co mice, with nominal P value less than 0.05. Data represent four mice per group for all groups, except those removed after not meeting quality control standards, including one Co sample in the lung and EpCAM⁺ cell analyses and one SPT + RV sample in the CD45⁺ analyses.