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. 2021 Dec 3;66(3):312–322. doi: 10.1165/rcmb.2021-0313OC

Figure 5.

Figure 5.

RSV-infected adult mice showed no IL-1β dependent increase of pulmonary IL-33. (A–D) IL-33 expression in RSV-infected adult mice with and without exogenous IL-1β: protein concentrations of IL-33 from whole-lung homogenates (A). The frequencies of IL-33–expressing cell subsets and also EpCAM+ cells (B), CD45+ cells (C), and CD31+ cells (D). *P < 0.05 and ***P < 0.001 compared between indicated groups using one-way ANOVA with Sidak multiple comparisons test. Data represent two independent experiments (mean ± SEM). Circles: neonatal; triangles: adult mice; open bars: vehicle; solid bars: IL-1β–treated groups. (E and F) Frequencies and number of EpiSPC in neonatal and adult mice with different treatments. ****P < 0.0001 compared between indicated groups using one-way ANOVA with Sidak multiple comparisons test. Data represent two independent experiments (mean ± SEM). Cycles: IL-1β; inverted triangles: vehicle; triangles: sham infection groups; solid bars: neonatal; open bars: adult mice. AR1 = adult mice infected with RSV, at 1 dp; AS = adult mice sham infected.