Table 3.

Odds Ratio (OR) of Exacerbations and Death in GOLD B1 Compared with GOLD B0 in Year 1, Year 2 and Year 3 Separately and in All Three Years Combined

	Year 1	Year 2	Year 3	Total Follow Up§
	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
1 moderate	1.48 (1.31–1.66)	1.60 (1.41–1.82)	1.29 (1.12–1.47)	1.58 (1.33–1.87)
≥2 moderate	2.13 (1.86–2.44)	2.00 (1.72–2.29)	2.19 (1.88–2.60)	2.60 (2.19–3.08)
≥1 severe	1.60 (1.39–1.84)	1.80 (1.56–2.08)	1.46 (1.25–1.70)	2.08 (1.76–2.45)
Dead*	1.26 (1.08–1.48)	1.42 (1.24–1.62)	1.32 (1.16–1.49)	1.85 (1.57–2.17)

Notes: ^§Cumulated number of events over the three years. Events were cumulated over the three-year period and counted hierarchical, so an individual with multiple events counted in the group with most severe events (moderate – severe – dead). All ORs are adjusted for age, sex, cohabitation status, comorbidity, BMI and smoking. All p-values comparing B0 and B1 were <0.05. *The number of dead patients was cumulated for all three years.