TABLE 6.
Compound 2 | Amino acid change (no. of passages in cell culture) with the following compound 1:
|
|||
---|---|---|---|---|
None | Calanolide A | Costatolide | Dihydrocostatolide | |
None | T139I | T139I, L100I | L100I | |
3TC | M184V | M184V, L100I (5) | M184V, L100I (6) | M184V, L100I (5) |
Diphenylsulfone | Y181C | V108I (6) | Y188H (6) | NDa |
E-BPTU | Y181C | K103N, V106I (6) | ND | ND |
α-APA | Y181C | ND | K103N (14) | ND |
UC10 | K101E, Y181C | Y188H (6) | K103N (5) | K103N (5) |
TSAO | Y181C | K101E (6) | K101E (6) | K101E (6) |
Diarylsulfone | Y181C | Y188H (13) | Y188H (11) | Y188H (8) |
ND, not determined.