TABLE 6.
Selection of virus strains resistant to two compounds (compounds 1 and 2)
| Compound 2 | Amino acid change (no. of passages in cell culture) with the following compound 1:
|
|||
|---|---|---|---|---|
| None | Calanolide A | Costatolide | Dihydrocostatolide | |
| None | T139I | T139I, L100I | L100I | |
| 3TC | M184V | M184V, L100I (5) | M184V, L100I (6) | M184V, L100I (5) |
| Diphenylsulfone | Y181C | V108I (6) | Y188H (6) | NDa |
| E-BPTU | Y181C | K103N, V106I (6) | ND | ND |
| α-APA | Y181C | ND | K103N (14) | ND |
| UC10 | K101E, Y181C | Y188H (6) | K103N (5) | K103N (5) |
| TSAO | Y181C | K101E (6) | K101E (6) | K101E (6) |
| Diarylsulfone | Y181C | Y188H (13) | Y188H (11) | Y188H (8) |
a
ND, not determined.