TABLE 4.
Sensitivities of topoisomerase IV and gyrase to fluoroquinolones
| Drug | IC50 (μM)a
|
|||
|---|---|---|---|---|
|
E. coli
|
S. aureus
|
|||
| Topoisomerase IVb | Gyrasec | Topoisomerase IV | Gyrase | |
| Trovafloxacin | 8.0 (0.53) | 0.52 (0.02) | 8.7 (0.29) | 18.8 (1.7) |
| Ciprofloxacin | 5.0 (0.18) | 0.42 (0.02) | 13.7 (1.9) | 25 (0) |
| Sparfloxacin | 9.3 (0.17) | 0.57 (0.02) | 40 (1.8) | 22 (1.5) |
a
IC50 drug concentration for half-maximal inhibition of catalytic activity. Values are given as means (standard errors).
b
Decatenation of kinetoplast DNA.
c
Supercoiling of relaxed pBR322.