Figure 3.

Comparison of Δglycosylation traits of patients admitted to ICU (red) or non-ICU (blue) treatment. Shown in the facets are the relative levels of ΔIgG1 (a) fucosylation, (b) galactosylation, (c) bisection and (d) sialylation at the time of hospitalization (left; n=159; 77 ICU and 82 non-ICU patients, respectively) and at the time of highest disease severity (right; n=144; 75 ICU and 69 non-ICU patients, respectively). The highest severity timepoint has been defined for each patient as the earliest possible timepoint with highest severity score during hospitalization. A Wilcoxon rank-sum test was used to compare ICU and non- ICU patients (Table S6). *, ****: p-value < 0·05, 0·0001, respectively. Glycosylation dynamics of ICU and non-ICU patients between day 10 and 25 are shown in Figure S8 (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.).