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% wound injury index of untreated control (circles), placebo NSs (triangles), free GPS (cross) and GPS-PLGA NSs, F5 (squares) in male Sprague–Dawley rats. Results are expressed as means ± SEM. (n=6 per group, at each day interval). GPS-PLGA NSs were statistically (p < 0.05) different from untreated control, placebo NSs and free GPS at all day intervals (3, 6, 9, and 12 days). Untreated control and placebo NSs were non-significant different (p > 0.05).
