TABLE 1.

Relative fitness of induced H37Rv rifampin-resistant mutant alleles

SSCP pattern	No. of replicates	Mean no. of generations of H37Rv		Location of mutation	Relative fitness
		Sensitive	Resistant
A1	4	8.65	6.95	His526→Tyr	0.80
A2	4	5.90	2.80	His526→Tyr	0.78
A3	3	6.73	4.62	His526→Asp	0.42
B1	5	7.88	8.30	Ser531→Leu	1.05
B2	3	7.73	7.43	Ser531→Leu	0.93
B3	3	6.83	6.29	Ser531→Leu	0.89
B4	3	9.60	4.83	Ser531→Leu	0.50
C1	2	5.68	10.04	His526→Arg	0.56
C2	5	6.40	1.35	His526→Arg	0.21