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. 2022 Feb 24;28(3):591–598. doi: 10.1038/s41591-022-01707-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Data are point estimates of HR (illustrated by the diamond symbol) and range of two-sided 95% CI of the HR. ^aStrata size adjusted estimate. Strata are defined as trial-level cardiovascular risk (SURPASS-4 forms one stratum, and all other trials form one stratum). ^bDerived from a Cox proportional hazards model with treatment (pooled tirzepatide versus pooled comparator), the subgroup variable and the treatment-by-subgroup interaction term as fixed effects, stratified by study-level cardiovascular risk (SURPASS-4 forms one stratum, and all other trials form one stratum) for subgroups other than stratum. Pre-specified subgroup analyses were by sex, age and baseline HbA1c; the rest of the analyses were post hoc. P value is from the Wald chi-square test. N, number of participants in the subgroup in population; n, number of participants in the specified category.