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. 2022 Mar 21;28(3):513–516. doi: 10.1038/s41591-022-01735-0

Extended Data Fig. 9. Normalization of polygenic risk scores.

Extended Data Fig. 9

Polygenic risk scores before (left) and after (right) centering and standardization for 5 populations within the UK Biobank. Standardized PRS scores have approximately zero mean and unit variance in each population.