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. 2022 Mar 21;28(3):513–516. doi: 10.1038/s41591-022-01735-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Predicted relative risk of disease. b, Predicted absolute disease risk. Autoimmune conditions (Type 1 diabetes, Vitiligo) exhibit greater variability in predicted disease risk as has been previously reported. Note: Risk for the embryo in case ID 7 carrying the APC risk allele, rs1801155, is based solely on that allele. A competing hazards method (Gail et al 1989) was used to calculate the absolute risk for atrial fibrillation, coronary artery disease, prostate cancer and Type 2 diabetes. Age- and ethnicity-specific overall and disease specific mortality rates were taken from the CDC Wonder database (Underlying Cause of Death 1999–2019). Individuals with >20% admixture of African/Asian ancestry as determined using ELAI software were not considered in this analysis.