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. 2022 Feb 28;28(3):535–544. doi: 10.1038/s41591-022-01695-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — (a) Forest plot showing Cox logistic regression multivariate analysis of progression-free survival. Error lines represent the 95% confidence interval of the hazard ratio. (b) Cross-validation AUC-ROC values obtained from LASSO models trained using 100-repeated fivefold stratified cross-validations (boxplots) and leave-one-dataset-out AUC-ROC values from LASSO models obtained by training the model using KEGG relative abundances and all but the corresponding PRIMM cohort (circles). PRIMM-NL (n = 55) and PRIMM-UK (n = 55). The lower and upper hinges of boxplots correspond to the 25th and 75th percentiles, respectively. The midline is the median. The upper and lower whiskers extend from the hinges to the largest (or smallest) value no further than ×1.5 interquartile range from the hinge, defined as the distance between the 25th and 75th percentiles.