Fig. 2.

The structure of SARS-CoV-2 bound to human ACE2 (hACE2) (Lan et al., 2020) and feline ACE2 (fACE2) (Wu et al., 2020). A, The structure of SARS-CoV-2 bound to hACE2 (6m0j). hACE2 is shown in green. The SARS-CoV-2 RBD core is shown in cyan and the receptor-binding motif in red. Disulfide bonds in the SARS-CoV-2 RBD are shown as sticks and indicated by arrows. The N-terminal helix of ACE2 responsible for binding is labeled. There is a Zn ion in the core of hACE2 molecule. B, The structure of SARS-CoV-2 bound to fACE2 (7c8d). fACE2 is shown in magenta. There is a Zn ion shown in the core of the fACE2 molecule, similar to hACE2, as shown in Figure A. The domains of SARS-CoV-2 RBD binding to fACE2 are shown in Figure A. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)