Fig. 3.

Prenatal exposure to maternal stress and overall structural covariance (modularity, transitivity and mean distance) in the young adult offspring from ELSPAC/VULDE cohort. Global network parameters did not vary significantly as a function of maternal stress. However, when trend-level values were considered as part of the five consecutive density thresholds, sex-specific group differences in global network transitivity and global mean distance were observed. Females with higher maternal stress exposure during the first half of pregnancy showed lower global network transitivity (density thresholds = 27–34%). Males with higher maternal stress exposure during the first half of pregnancy showed lower global mean distance (density thresholds = 18–24%) while males with higher maternal stress exposure during the second half of pregnancy shower higher global mean distance (density thresholds = 31–40%). High stress group is depicted in red, low stress group is depicted in blue, solid line indicates p ≤ 0.05, dashed line indicates p ≤ 0.10.