Table 2.
Association of BMI category with incident obesity-related disease and multimorbidity
|
First disease |
Second disease |
Third disease |
Fourth disease |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Incident cases | HR (95% CI)* | PAF (95% CI) | Incident cases | HR (95% CI)* | PAF (95% CI) | Incident cases | HR (95% CI)* | PAF (95% CI) | Incident cases | HR (95% CI)* | PAF (95% CI) | |
| Finnish cohorts | ||||||||||||
| Underweight (n=1476) | 161 | 0·80 (0·69- to 0·94) | −0·2% (−0·4 to −0·1) | 29 | 0·95 (0·66 to 1·37) | 0% (−0·3 to 0·3) | 8 | .. | .. | 1 | .. | .. |
| Healthy weight (n=55 857) | 9373 | 1 (ref) | 0% (ref) | 1676 | 1 (ref) | 0% (ref) | 309 | 1 (ref) | 0% (ref) | 62 | 1 (ref) | 0% (ref) |
| Overweight (n=24 495) | 6813 | 1·53 (1·49 to 1·58) | 9·6% (8·9 to 10·2) | 1764 | 1·89 (1·77 to 2·03) | 12·1% (10·9 to 13·3) | 431 | 2·30 (1·98 to 2·66) | 13·4% (11·3 to 15·4) | 104 | 2·67 (1·94 to 3·68) | 13·3% (9·6 to 16·3) |
| Obesity (n=14 867) | 5672 | 2·83 (2·74 to 2·93) | 19·9% (19·3 to 20·5) | 2058 | 5·17 (4·84 to 5·53) | 34·4% (33·2 to 35·5) | 645 | 8·18 (7·12 to 9·39) | 45·2% (43·1 to 47·0) | 195 | 12·39 (9·26 to 16·58) | 55·2% (50·9 to 57·5) |
| Class 1 obesity (n=12 496) | 4519 | 2·63 (2·53 to 2·72) | 14·8% (14·3 to 15·3) | 1565 | 4·61 (4·30 to 4·95) | 24·9% (24·1 to 25·7) | 454 | 6·77 (5·85 to 7·85) | 30·4% (29·0 to 31·5) | 127 | 9·56 (7·02 to 13·02) | 34·9% (32·2 to 35·9) |
| Class 2 obesity (n=1839) | 875 | 3·80 (3·54 to 4·07) | 3·8% (3·5 to 4·0) | 358 | 7·39 (6·59 to 8·29) | 6·5% (6·0 to 7·0) | 136 | 13·63 (11·12 to 16·71) | 9·8% (8·9 to 10·6) | 53 | 25·55 (17·63 to 37·04) | 14·7% (13·1 to 15·9) |
| Class 3 obesity (n=532) | 278 | 4·99 (4·43 to 5·62) | 1·5% (1·4 to 1·7) | 135 | 12·43 (10·42 to 14·82) | 3·4% (2·9 to 3·8) | 55 | 25·22 (18·91 to 33·64) | 5·4% (4·6 to 6·4) | 15 | 33·56 (19·04 to 59·13) | 5·7% (4·1 to 7·4) |
| UK Biobank cohort | ||||||||||||
| Underweight (n=2387) | 423 | 1·09 (0·99 to 1·20) | <0·1% (0·0 to 0·1) | 74 | 1·09 (0·87 to 1·38) | 0% (−0·1 to 0·1) | 20 | 1·46 (0·94 to 2·28) | 0·2% (0·0 to 0·4) | 5 | .. | .. |
| Healthy weight (n=150 423) | 25787 | 1 (ref) | 0% (ref) | 4620 | 1 (ref) | 0% (ref) | 949 | 1 (ref) | 0% (ref) | 203 | 1 (ref) | 0% (ref) |
| Overweight (n=188 761) | 43 734 | 1·28 (1·26 to 1·30) | 8·9% (8·4 to 9·4) | 9149 | 1·36 (1·31 to 1·41) | 10·3% (9·2 to 11·4) | 2032 | 1·40 (1·30 to 1·51) | 10·3% (8·1 to 12·4) | 482 | 1·49 (1·27 to 1·76) | 11·1% (6·9 to 14·9) |
| Obesity (n=100 510) | 31 931 | 1·88 (1·85 to 1·91) | 15·2% (14·8 to 15·5) | 8638 | 2·48 (2·39 to 2·57) | 22·6% (21·8 to 23·3) | 2390 | 3·12 (2·89 to 3·36) | 29·1% (27·6 to 30·5) | 691 | 3·99 (3·41 to 4·68) | 35·9% (33·0 to 38·4) |
| Class 1 obesity (n=73 494) | 21 912 | 1·71 (1·68 to 1·74) | 8·9% (8·6 to 9·2) | 5569 | 2·12 (2·04 to 2·20) | 12·4% (11·9 to 12·9) | 1433 | 2·47 (2·27 to 2·68) | 14·6% (13·6 to 15·6) | 388 | 2·95 (2·49 to 3·51) | 16·9% (14·9 to 18·5) |
| Class 2 obesity (n=19 767) | 7048 | 2·24 (2·18 to 2·30) | 4·2% (4·0 to 4·3) | 2051 | 3·15 (2·99 to 3·32) | 6·4% (6·1 to 6·7) | 623 | 4·37 (3·95 to 4·84) | 9·0% (8·5 to 9·6) | 198 | 6·18 (5·07 to 7·53) | 12·0% (11·0 to 13·0) |
| Class 3 obesity (n=7249) | 2971 | 2·90 (2·79 to 3·01) | 2·4% (2·3 to 2·5) | 1018 | 4·95 (4·62 to 5·30) | 4·3% (4·1 to 4·5) | 334 | 7·53 (6·64 to 8·54) | 6·4% (5·9 to 6·9) | 105 | 10·64 (8·39 to 13·50) | 8·2% (7·3 to 9·1) |
Data are n unless otherwise stated. HR=hazard ratio. PAF=population attributable fraction.
*
Adjusted for age, sex, ethnicity (UK Biobank), cohort (Finnish cohorts), education, and neighbourhood deprivation.