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. 2022 Mar 21;13(3):254. doi: 10.1038/s41419-022-04529-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Rescue experiment design. At 6 weeks after the diabetic mice model had been successfully established, OE-BMP-7 plasmid was injected i.v. every week for 6 consecutive weeks, and mice were killed at the end of 12 weeks.b Urinary microalbumin/urinary creatinine level in NC + Control group and the DM group (DM + Control, DM + Vector, DM + BMP-7) mice,*P < 0.05 (n = 6). c Blood glucose, d Triglyceride, e Total cholesterol levels in the NC group (NC + Control, NC + Vector, NC + BMP-7) and DM group (DM + Control, DM + Vector, DM + BMP-7) mice,*P < 0.05 (n = 6). Histological changes of kidneys in the NC group and DM group f (hematoxylin-eosin staining), g (Masson’s trichrome staining)black box indicates the enlarged area of details for fibrosis(magnification ×400). h Renal tubular lumen area was analyzed in each group from six random fields (200×), *P < 0.05 (n = 6). i Positive staining density of Masson’s trichrome staining was analyzed in each group from six random fields (200×), *P < 0.05 (n = 6).