Figure 5.

Transferability of results via FMTs in AIMD WT mice. A Study design. B α-diversity measured as observed ASVs indicated depletion post antibiotics and bowel cleanse and reshaping post FMT. C β-diversity measured by Bray–Curtis distance. While Sham groups co-located and ABX and PEG groups co-located, animals receiving FMTs were distinct but located separately. The ABX group recovered partially. For analysis, the group receiving Wt + CRL FMT (abnormal α- and β-diversity) was fainted throughout microbial analysis, although no impact on behavioral data was observed. D Taxonomic analysis of phyla levels in fecal samples post FMT. Besides in animals receiving Wt + CRL, no major differences were found between groups. E Barnes maze experiment for examination of differences in memory and learning. Results were normalized to sham group to reduce complexity of analysis. Analysis revealed that AIMD WT mice receiving none, or FMT from untreated APP/PS1 mice, performed similar or worse than all other groups. Significance was determined as in prior experiments of microbiome and Barnes maze analysis. The probe trial results were compared to ABX group only. Significance: *p < 0.05, **p < 0.01, ***p < 0.001.