Table 8.
Genes With Altered Expression According to RNA-seq Data Involved in HCC Cell Tumorigenesis and CSC Properties
| Gene | NC vs shMBD2a |
NC vs MBD2c OE |
||||
|---|---|---|---|---|---|---|
| NC | sh2a | log2 (fold change) | NC | MBD2c | log2(fold change) | |
| FZD3 | 6.7542 | 2.13453 | −3.4521583 | 5.5828213 | 1.2648953 | −2.921362 |
| BCL6 | 10.5128 | 5.66543 | −1.19144 | 11.5697 | 7.97015 | −0.453377 |
| FN1 | 97.165 | 59.348 | −1.0632 | 101.797 | 78.634518 | −1.033386 |
| CXXC4 | 2.9779 | 0.056784 | −4.5743 | 1.24439 | 0.60213 | −1.111473 |
| NRP1 | 64.612 | 35.478 | −0.694769 | 72.787 | 96.0794 | −0.564434 |
| POU5F1 | 4.643 | 1.8953 | −1.10862 | 5.3391 | 2.1555 | −0.533557 |
| PTPRJ | 21.597 | 12.274 | −0.627586 | 39.665 | 25.8322 | −0.664897 |
| CTNNB1 | 210.5 | 86.614 | −0.626239 | 230.6745 | 155.633 | −0.565406 |
| SNX9 | 13.236 | 12.969 | −0.607511 | 29.64685 | 14.438397 | −0.678946 |
| FBP1 | 19.12 | 43.029 | 0.909213 | 19.32576 | 39.1543 | 1.02807 |
| JAK2 | 5.2499 | 0.9521 | −3.83621 | 4.62095 | 1.94382 | −0.574803 |
| SOX2 | 11.33 | 2.467552 | −2.38735 | 11.45719 | 2.6532866 | −1.21284 |
| HMGB1 | 371.36 | 57.828 | −2.33299 | 335.593 | 102.706 | −0.675133 |
| SATB1 | 7.97543 | 2.462 | −2.0718 | 6.7554 | 3.56073 | −0.555625 |
| LRP6 | 7.7443 | 3.63432 | −1.9576 | 8.9765 | 6.3201424 | −0.576317 |
| CYP1B1 | 39.53379 | 11.43783 | −1.84371 | 37.1218 | 14.8415 | −1.21455 |
| SNAI1 | 8.3776 | 2.03224 | −1.78365 | 7.7558 | 0.8656907 | −1.876549 |
| FZD1 | 19.5336 | 7.5432299 | −1.51276 | 18.0155 | 10.5791 | −0.685639 |
| RRAD | 2.15321 | 0.4356 | −1.42891 | 4.6547 | 2.03482 | −0.350023 |
| NET1 | 39.532 | 15.63453 | −1.13324 | 42.0497 | 23.6004 | −0.473372 |
CSC, Cancer stem cell; HCC, hepatocellular carcinoma.