Table 2.

Prediction of neuropsychiatric symptom severity (MBI-C total score) in tau-positive individuals.

Dependent variable	Predictors in model, n	R2	Adj R2	t-statistic for regression coefficient					Spearman partial correlation, ρ
				Mid-caudal LC signal	Tau-PET, temporal ROI	Cortical amyloid-PET	Cortical gray matter volume	CDR	Mid-caudal LC signal
MBI, total score	4; 51	0.44	0.39	2.85**	Excluded	Excluded	Excluded	4.99***	0.32*
	5; 51	0.49	0.44	3.30**	2.25*	Excluded	Excluded	2.99**	0.35*
	6; 51	0.50	0.43	3.23**	2.08*	0.52	Excluded	2.97**	0.35*
	8; 51 (full model)	0.51	0.41	3.31**	1.70	0.63	−0.42	2.70*	0.35*
MBI, impulse dyscontrol	8; 51	0.36	0.24	3.32**	1.70	1.07	−1.10	0.24	0.44**

All analyses included age and sex as covariates. Analysis including cortical gray matter volume also included estimated total intracranial volume as a covariate.

*p < 0.05; **p < 0.01; ***p < 0.001.