Fig. 2. Growth responses according to idiopathic vs. organic GHD and isolated vs. MPHD in children and adolescents with GHD during the 3 years of GH treatment. (A) ΔHt SDS, (B) ΔPAH SDS, (C) ΔIGF-1 SDS, and (D) ΔIGFBP-3 SDS. The values are presented as mean ± 95% confident interval. The different lowercase letters on the bars indicate significant differences between subgroups.

Ht = height, SDS = standard deviation score, PAH = predicted adult height, IGF-1 = insulin like growth factor-1, IGFBP-3 = insulin like growth factor-binding protein-3, IGHD = isolated growth hormone deficiency, MPHD = multiple pituitary hormone deficiency.

^**P < 0.01; ^***P < 0.001.