Fig. 3. Growth responses to the 3-year GH treatment in children and adolescents with idiopathic or organic GHD. (A) ΔBone age, (B) ΔBMI SDS, (C) ΔHt SDS, (D) Ht SDS, (E) Ht SDS minus MPH SDS, (F) IGF-1 SDS, and (G) IGFBP-3 SDS. All values are presented as mean ± 95% confident interval. The different lowercase letters indicate significant differences between groups.

GH = growth hormone, GHD = growth hormone deficiency, BMI = body mass index, SDS = standard deviation score; Ht = height, MPH = mid-parental height, IGF-1 = insulin like growth factor-1, IGFBP-3 = insulin like growth factor-binding protein-3.

^*P < 0.05; ^**P < 0.01; ^***P < 0.001.