. 2022 Mar 15;37(11):e90. doi: 10.3346/jkms.2022.37.e90

Table 1. Auxological and biochemical characteristics in participants.

Parameters	Idiopathic GHD				Organic GHD				P value^b
Parameters	Total (N = 131)	Male (n = 83)	Female (n = 48)	P value^a	Total (N = 32)	Male (n = 17)	Female (n = 15)	P value^a	P value^b
CA, yr	7.50 ± 2.91	7.57 ± 3.18	7.38 ± 2.40	0.926	9.72 ± 3.58	9.53 ± 3.51	9.93 ± 3.76	0.761	0.001
BA, yr	5.45 ± 2.92	5.51 ± 3.25	5.33 ± 2.30	0.698	7.24 ± 3.73	7.09 ± 3.29	7.47 ± 4.53	0.821	0.018
CA-BA, yr	1.89 ± 0.99	1.92 ± 1.04	1.83 ± 0.92	0.631	2.04 ± 1.28	2.18 ± 1.25	1.82 ± 1.37	0.520	0.530
Ht SDS	−2.84 ± 0.75	−2.77 ± 0.72	−2.96 ± 0.80	0.232	−2.21 ± 1.50	−2.54 ± 1.33	−1.83 ± 1.64	0.201	0.043
Wt SDS	−1.95 ± 1.12	−2.04 ± 0.94	−1.80 ± 1.37	0.340	−1.17 ± 1.49	−1.57 ± 1.01	−0.70 ± 1.82	0.129	0.011
BMI SDS	−0.31 ± 1.22	−0.49 ± 1.11	0.01 ± 1.35	0.055	0.06 ± 1.23	−0.20 ± 0.85	0.35 ± 1.53	0.243	0.099
MPH SDS	−0.75 ± 0.77	−0.61 ± 0.70	−0.98 ± 0.84	0.013	0.09 ± 0.59	−0.06 ± 0.51	0.22 ± 0.64	0.243	< 0.001
PAH SDS	−1.81 ± 1.10	−1.66 ± 1.07	−2.10 ± 1.13	0.205	−0.33 ± 2.02	−0.20 ± 2.21	−0.59 ± 1.87	0.770	0.031
Prepubertal^c	44 (86.2)	17 (85.0)	27 (87.1)	0.832	14 (82.4)	7 (70.0)	7 (100)	0.110	0.693
Ht SDS–MPH SDS	−2.04 ± 0.90	−2.06 ± 0.83	−2.01 ± 1.04	0.821	−2.32 ± 0.94	−2.28 ± 1.08	−2.35 ± 0.84	0.862	0.179
IGF-1 SDS	−0.71 ± 0.92	−0.67 ± 0.90	−0.78 ± 0.98	0.992	−0.45 ± 2.78	−0.03 ± 3.50	−0.92 ± 1.79	1.000	0.045
IGFBP-3 SDS	−0.44 ± 1.75	−0.31 ± 1.54	−0.70 ± 2.12	0.373	−0.45 ± 3.03	−0.51 ± 3.72	−0.38 ± 1.92	0.306	0.270
Peak GH level on GHST, μg/L	6.47 ± 2.54	6.58 ± 2.46	6.28 ± 2.69	0.683	2.22 ± 2.42	2.26 ± 2.74	2.18 ± 2.09	0.925	< 0.001
Initial GH dose, mg/kg/week	0.23 ± 0.05	0.23 ± 0.05	0.23 ± 0.04	0.494	0.20 ± 0.07	0.23 ± 0.06	0.17 ± 0.07	0.017	0.026
Mean GH dose during 3 yr of GH treatment, mg/kg/week	0.23 ± 0.04	0.23 ± 0.04	0.23 ± 0.04	0.736	0.19 ± 0.06	0.22 ± 0.04	0.17 ± 0.07	0.034	0.001

Values are presented as number (%) or mean ± standard deviation.

GHD = growth hormone deficiency, CA = chronological age, BA = bone age, Ht = height, SDS = standard deviation score, Wt = weight, BMI = body mass index, MPH = mid-parental height, PAH = predicted adult height, IGF-1 = insulin like growth factor-1, IGFBP-3 = insulin like growth factor-binding protein-3, GH = growth hormone, GHST = growth hormone stimulation test.

P values are calculated with independent t-test or Wilcoxon rank sum test: ^amale vs. female; ^bIGHD vs. OGHD.

^cThis variable was analyzed from only available participants: IGHD (n = 51) and OGHD (n = 17).