Table 3. Changes in growth velocity and mean GH dosage after GH treatment in the idiopathic and organic GHD groups.

GH therapy		Total (N = 163)	Idiopathic GHD (n = 131)	Organic GHD (n = 32)	P valuea
					Non-adjusted	Age-adjusted	Sex-adjusted	Puberty-adjusted	All adjusted
Growth velocity (cm/year)
	1st year	8.84 ± 2.21	9.28 ± 1.87	7.30 ± 2.58	< 0.001	0.009	< 0.001	< 0.001	0.003
	2nd year	7.48 ± 1.94	7.76 ± 1.70	6.33 ± 2.43	0.001	0.009	< 0.001	< 0.001	0.001
	3rd year	6.66 ± 1.88	6.69 ± 1.70	6.52 ± 2.54	0.880	0.644	0.517	0.088	0.925
Mean GH dose (mg/kg/week)
	1st year	0.22 ± 0.05	0.23 ± 0.04	0.20 ± 0.06	0.021	0.206	< 0.001	< 0.001	< 0.001
	2nd year	0.22 ± 0.04	0.23 ± 0.04	0.20 ± 0.06	0.007	0.207	< 0.001	0.001	0.001
	3rd year	0.22 ± 0.05	0.23 ± 0.04	0.19 ± 0.06	0.001	0.249	< 0.001	0.001	0.001

GH = growth hormone, GHD = growth hormone deficiency.

^aNon-adjusted P values are calculated with independent t-test or Wilcoxon rank sum test, and others are analyzed by analysis of covariance with covariates including age, sex, and puberty.