Table 3.

Calculated IOA and IOR for the final diagnosis and IOA for the individual nCLE malignancy criteria based on the scoring performances of the five raters during both validations sessions

	κ value
Final diagnosis
IOA	0.78 (0.70–0.86)
IOR	0.82±0.05
Enlarged pleomorphic cells	0.53 (0.44-0.61)
Dark clumps	0.49 (0.41–0.58)
Directional streaming	0.46 (0.38–0.55)

The data are presented as the IOA κ (95% CI) unless stated otherwise. Landis-Koch interpretation system: poor <0.2, fair 0.21–0.4, moderate 0.41–0.6, substantial 0.61–0.8 and excellent 0.81–1.

IOA, inter-observer agreement; IOR, intra-observer reliability was calculated by comparing the first and second validation session.; nCLE, needle-based confocal laser endomicroscopy.