Table 3.

Parameters associated with postoperative disease recurrence and overall mortality of ccRCC patients after adjusting for confounding variables in the univariate and multivariate Cox regression analyses

Variables	Disease-free survival			Overall survival
	Univariate	Multivariate		Univariate	Multivariate
	P value	HR (95% CI)	P value	P value	HR (95% CI)	P value
Sex (male vs female)	0.713			0.072
Age at surgery (>60 years vs <60 years)	0.222			0.007	2.57 (1.14 to 5.74)	0.022
Pathological T stage (pT3/4 vs pT1/2)	<0.001	1.94 (1.08 to 3.46)	0.026	<0.001
Tumor grade (G3/4 vs G1/2)	<0.001	3.00 (1.68 to 5.36)	<0.001	<0.001	4.74 (2.18 to 10.27)	<0.001
Venous invasion (positive vs negative)	0.056			0.190
Tumor size (>60 mm vs <60 mm)	<0.001			0.009
TLS (positive vs negative)	<0.001	2.57 (1.50 to 4.40)	0.001	<0.001	3.04 (1.42 to 6.48)	0.004

ccRCC, clear cell renal cell carcinoma; TLS, tertiary lymphoid structure.