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. Author manuscript; available in PMC: 2022 Mar 22.
Published in final edited form as: J Am Chem Soc. 2022 Feb 10;144(7):3174–3181. doi: 10.1021/jacs.1c12750

Figure 1.

Figure 1.

Architectures of siRNA-SNAs. (A) Hybridized architecture, in which the passenger strand is attached to the core and the guide strand is hybridized to it with low duplexing efficiency, and (B) hairpin-like architecture, in which a hairpin-like siRNA, a single RNA strand composed of a duplex and a hairpin-like region of PEG spacers, is attached to the core with high duplexing efficiency. Detailed chemical structures are shown in Figure S1.