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Hairpin-like design increases duplex loading of siRNA-SNAs. (A) DLS of bare gold nanoparticles and hybridized and hairpin-like siRNA-SNAs. Diameter shown is number mean. Error bars are SD of 10 measurements (****P ≤ 0.0001). (B) siRNA duplex loading for each SNA architecture. Error bars are SD of 3 batches of SNAs (****P ≤ 0.0001).
