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. Author manuscript; available in PMC: 2022 Mar 22.
Published in final edited form as: J Am Chem Soc. 2022 Feb 10;144(7):3174–3181. doi: 10.1021/jacs.1c12750

Figure 4.

Figure 4.

Hairpin-like design increases serum stability and decreases cytotoxicity of siRNA-SNAs. (A) Degradation of siRNA-SNAs in serum. Error bars are SD of 3 experimental replicates. (B) Half-lives of siRNA-SNAs in serum, derived from curves in (A). Error bars are SD of 3 experimental replicates (***P ≤ 0.001). (C) Cytotoxicity of siRNA-SNAs. Dotted lines are 95% confidence interval (CI). Error bars are SD of 3 biological replicates. (D) LD50 of siRNA-SNAs, derived from curves in (C). Error bars are SD of 3 biological replicates (**P ≤ 0.01).