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. Author manuscript; available in PMC: 2022 Mar 22.
Published in final edited form as: Neurobiol Aging. 2020 Nov 2;101:297.e1–297.e4. doi: 10.1016/j.neurobiolaging.2020.10.030

Table 1.

Burden tests for UQCRC1 in the AMP-PD cohort

Burden test All variants Coding variants Nonsynonymous variants
NumVar NumPolyVar p-value NumVar NumPolyVar p-value NumVar NumPolyVar p-value
Zeggini 73 54 0.562 18 13 0.619 12 9 0.721
SKAT-O 73 54 0.77 18 13 0.586 12 9 0.712
SKAT 73 54 0.865 18 13 0.476 12 9 0.594
Madson-Browning 73 54 0.487 18 13 0.046 12 9 0.109
Fp 73 54 0.712 18 13 0.489 12 9 0.898
CMC 73 54 0.596 18 13 0.629 12 9 0.731

Key: AMP-PD, Accelerating Medicines Partnership–Parkinson’s disease; CMC, combined multivariate and collapsing; NumPolyVar, number of polymorphic genotypes; NumVar, number of variants; SKAT, sequence kernel association test; SKAT-O, sequence kernel association test optimized version.