Skip to main content
. Author manuscript; available in PMC: 2022 Mar 22.
Published in final edited form as: Science. 2021 Jun 17;373(6553):420–425. doi: 10.1126/science.abg7917

Fig. 1. NRG1.1 CC-R resembles the ZAR1 and MLKL four-helical bundle.

Fig. 1.

(A) Structural overlay of 7K(R)E (PBD: 7L7V) and 2KE (7L7W) with 2KE in green, 7K(R)E four-helical bundle (4HB) in cyan, and 7K(R)E N-terminal region in yellow. (B) Structural overlay of 2KE in green and the ZAR1 4HB (6J5V) structure in light purple. (C) Structural overlay of 2KE in green and mMLKL 4HB (4BTF) in orange. (D) Structural overlay of 2KE in green and hMLKL 4HB (2MSV) in magenta. (E) Conserved F86/I75/I76 and L69/I57/L58 shown in sticks in the α3 helix of superimposed 2KE, mMLKL and hMLKL 4HB structures, respectively. (F and G) In planta (N. benthamiana) phenotypes at 2 days after induction and protein accumulation of WT NRG1.1 CC-R and structure-derived mutants. EV, empty vector.