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. Author manuscript; available in PMC: 2022 Mar 22.
Published in final edited form as: Science. 2021 Jun 17;373(6553):420–425. doi: 10.1126/science.abg7917

Fig. 5. NRG1.1 D485V forms nonselective cation channel.

Fig. 5.

(A) Whole-cell current recorded in voltage ramp (+50 to ‒200 mV) in a CaCl2 bath solution. (B) Whole-cell current recorded in voltage ramp (+50 to ‒200 mV) in a TEA-Cl bath solution. (C) Mean current recorded at ‒200 mV during experiments in (A) and (B). (D) Reversal potential (Erev) and relative ion permeability (PX/PCs) measured in voltage ramp experiments in CaCl2 or MgCl2 solutions in HEK293 cells expressing NRG1.1 D485V (N = 10 Ca2+ and N = 8 Mg2+). Letters indicate statistical difference (ANOVA with post hoc Tukey, P < 0.05).