2. Adverse events results.

Sub‐group	Study	Type of adverse event	DCS		Placebo		RR (95% CI)
			Events	Total	Events	Total
Adults OCD	Kushner 2007	“Any” or “all” adverse events	4	15	3	17	1.51 (0.40 to 5.69)
	Storch 2007	“Any” or “all” adverse events	3	12	3	12	1.00 (0.25 to 4.00)
	Wilhelm 2008	“Any” or “all” adverse events	No events were reported
Adults PD	Otto 2010	“Any” or “all” adverse events	No events were reported
	Siegmund 2011	"Harms" or "unintended effects"	No events were reported
Adults PTSD	Difede 2014	“Any” or “all” adverse events	No events were reported
	Litz 2012	Serious adverse events	No events were reported
Adults SAnD	Cameron 2005	Any adverse events excluding serious adverse events	10	20	12	19	0.79 (0.45 to 1.38)
	Guastella 2008	“Any” or “all” adverse events	No events were reported
	Hofmann 2006	Vivid nightmares in 1 patient and euphoric mood and increased energy in another	2	12	0	15	6.15 (0.32 to 117.21)
	Sheerin 2014	“Any” or “all” adverse events, mild (dizziness, fatigue)	0	7	2	9	0.25 (0.01 to 4.50)
Adults SPh	Ressler 2004	“Any” or “all” adverse events, not systematically obtained	No events were reported
	Tart 2013	“Any” or “all” adverse events	No events were reported
Children and adolescents OCD	Farrell 2013	Treatment related adverse events	No events were reported
	Mataix‐Cols 2014	Drug related adverse events	No events were reported
	Storch 2010	“Any” or “all” adverse events	No events were reported
Children and adolescents PTSD	Scheeringa 2014	“Any” or “all” adverse events	7	29	7	28	0.97 (0.39 to 2.40)