Comparison 2. DCS and cognitive and behavioural therapies versus placebo and cognitive and behavioural therapies ‐ children and adolescents.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Treatment efficacy: treatment responders ‐ end of treatment	4	121	Risk Ratio (M‐H, Random, 95% CI)	1.01 [0.78, 1.31]
1.1 OCD	3	74	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.94, 1.35]
1.2 PTSD	1	47	Risk Ratio (M‐H, Random, 95% CI)	0.70 [0.44, 1.10]
2 Treatment efficacy: treatment responders ‐ 3‐12 month follow up	3	91	Risk Ratio (M‐H, Random, 95% CI)	0.86 [0.67, 1.09]
2.1 OCD	2	44	Risk Ratio (M‐H, Random, 95% CI)	0.93 [0.71, 1.21]
2.2 PTSD	1	47	Risk Ratio (M‐H, Random, 95% CI)	0.70 [0.44, 1.10]
3 Treatment acceptability: withdrawals from treatment ‐ end of treatment	4	131	Risk Ratio (M‐H, Random, 95% CI)	0.90 [0.17, 4.69]
3.1 OCD	3	74	Risk Ratio (M‐H, Random, 95% CI)	0.21 [0.01, 4.08]
3.2 PTSD	1	57	Risk Ratio (M‐H, Random, 95% CI)	1.45 [0.46, 4.59]
4 In remission ‐ end of treatment	2	44	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.66, 2.16]
4.1 OCD	2	44	Risk Ratio (M‐H, Random, 95% CI)	1.19 [0.66, 2.16]
5 In remission ‐ 3‐12 month follow up	2	44	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.69, 1.61]
5.1 OCD	2	44	Risk Ratio (M‐H, Random, 95% CI)	1.05 [0.69, 1.61]
6 Condition‐specific anxiety symptoms ‐ end of treatment	4	131	Std. Mean Difference (IV, Random, 95% CI)	0.07 [‐0.55, 0.69]
6.1 OCD (Y‐BOCS)	3	74	Std. Mean Difference (IV, Random, 95% CI)	‐0.22 [‐0.70, 0.25]
6.2 PTSD (Child PTSD Symptom Scale)	1	57	Std. Mean Difference (IV, Random, 95% CI)	0.70 [0.17, 1.24]
7 Condition‐specific anxiety symptoms ‐ 3‐12 month follow up	3	91	Std. Mean Difference (IV, Random, 95% CI)	0.23 [‐0.32, 0.78]
7.1 OCD (Y‐BOCS)	2	44	Std. Mean Difference (IV, Random, 95% CI)	‐0.06 [‐0.65, 0.54]
7.2 PTSD (Child PTSD Symptom Scale)	1	47	Std. Mean Difference (IV, Random, 95% CI)	0.62 [0.03, 1.21]
8 Co‐morbid symptoms of depression ‐ end of treatment	3	114	Std. Mean Difference (IV, Random, 95% CI)	0.08 [‐0.52, 0.69]
8.1 OCD (BDI‐Y and CDI)	2	57	Std. Mean Difference (IV, Random, 95% CI)	‐0.24 [‐0.77, 0.28]
8.2 PTSD (CDI)	1	57	Std. Mean Difference (IV, Random, 95% CI)	0.60 [0.06, 1.13]
9 Co‐morbid symptoms of depression ‐ 3‐12 month follow up	2	84	Std. Mean Difference (IV, Random, 95% CI)	0.09 [‐0.56, 0.74]
9.1 OCD (BDI‐Y)	1	27	Std. Mean Difference (IV, Random, 95% CI)	‐0.30 [‐1.06, 0.46]
9.2 PTSD (CDI)	1	57	Std. Mean Difference (IV, Random, 95% CI)	0.37 [‐0.16, 0.89]
10 Co‐morbid anxiety symptoms ‐ end of treatment	3		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
10.1 OCD (MASC)	2	47	Std. Mean Difference (IV, Random, 95% CI)	‐0.35 [‐0.93, 0.23]
10.2 PTSD (SCARED)	1	57	Std. Mean Difference (IV, Random, 95% CI)	0.80 [0.26, 1.34]
11 Co‐morbid anxiety symptoms ‐ 3 month follow up	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
11.1 PTSD (SCARED)	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]