Table 4.
PCA of the methylation levels of field cancerization-specific DMRs in tumor samples revealed significant associations (in bold) with some clinical features
P value | PC1 | PC2 | PC3 |
---|---|---|---|
Age | 0.007 | 1.081e − 13 | 3.091e − 05 |
Sex | 0.374 | 0.1621 | 0.0026 |
T-stage | 0.1714 | 0.9696 | 0.054 |
N-stage | 0.2857 | 0.2769 | 0.9209 |
Histology | 0.0728 | 0.0003 | 0.0792 |
Smoking status | 0.2904 | 0.7241 | 0.3701 |
Tumor size | 0 | 0.223 | 0 |
ADJ—tumor-adjacent normal tissue, DIS—tumor-distant normal tissue, DMR—differential methylation region, TUM—surgically-resected tumor