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. 2022 Mar 22;14:32. doi: 10.1186/s13073-022-01038-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Regional plots for genetic associations between SELP locus and epigenetic age acceleration (EAA)-Horvath (A), HLA locus, and EAA-Hannum (B). ^aEach dot represents the test result for one SNP. ^bX-axis is the genomic location along each chromosome, and Y-axis is -log10 of P value. ^cThe red horizontal line corresponds to the P value of 5×10^-8. ^dSNP depicted in diamond is the index SNP for the region, and all other SNPs were depicted as circles and their correlations (i.e., pair-wise linkage disequilibrium) with the index SNP was warm/cool color-coded