Table 3.

Factors associated with long-term relative survival in 1324 patients that survived 90 days after admission

Factors	Unadjusted hazard ratio	P value	Adjusted hazard ratio	P value
	(95% CI)		(95% CI)
Age (years)
< 65	1 (reference)		1 (reference)
65—74	1.05 (0.81 to 1.36)	0.69	1.22 (0.94 to 1.61)	0.12
75—79	0.93 (0.67 to 1.29)	0.66	1.16 (0.83 to 1.62)	0.37
80 – 84	1.02 (0.71 to 1.46)	0.91	0.92 (0.64 to1.33)	0.65
85 – 89	1.36 (0.83 to 2.25)	0.23	0.86 (0.52 to 1.42)	0.56
≥ 90	1.26 (0.44 to 3.60)	0.67	1.17 (0.56 to 2.47)	0.68
Female sex	1.14 (0.92 to 1.41)	0.23	1.28 (1.04 to 1.58)	0.021
Calendar year
1980–1989	1 (reference)		1 (reference)
1990–1999	0.95 (0.70 to 1.29)	0.74	0.68 (0.50 to 0.93)	0.016
2000–2009	0.69 (0.51 to 0.93)	0.016	0.55 (0.40 to 0.74)	< 0.001
2010–2016	0.58 (0.42 to 0.82)	0.002	0.43 (0.31 to 0.61)	< 0.001
CCI	1.36 (1.20 to 1.55)	< 0.001	1.24 (1.07 to 1.43)	0.004
ASA score
1–2	1 (reference)		1 (reference)
3	1.32 (1.06 to 1.65)	0.013	1.27 (0.98 to 1.64)	0.066
4–5	4.65 (3.07 to 7.04)	< 0.001	1.95 (1.23 to 3.12)	0.005
Emergency surgery	2.09 (1.62 to 2.68)	< 0.001	1.42 (1.09 to 1.86)	0.010
TNM-stage
I	1 (reference)		1 (reference)
II	1.75 (0.66 to 4.65)	0.26	1.36 (0.69 to 2.68)	0.37
III	6.61 (2.61 to 16.74)	< 0.001	4.71 (2.47 to 8.99)	< 0.001
IV	44.81 (17.96 to 111)	< 0.001	3.39 (1.68 to 6.85)	0.001
Unknown	24.29 (8.67 to 68.05)	< 0.001	1.48 (0.65 to 3.34)	0.35
Treatment intent categories
Curative intent
Major resection	1 (reference)		1 (reference)
Polypectomy	1.62 (0.71 to 3.74)	0.25	3.82 (1.54 to 9.48)	0.004
Non-curative intent
Major resection	16.13 (12.51 to 20.80)	< 0.001	9.50 (5.94 to 15.18)	< 0.001
Bypass/stoma	25.50 (16.59 to 39.20)	< 0.001	19.38 (10.82 to 34.69)	< 0.001
Best supportive care	21.22 (15.74 to 28.61)	< 0.001	22.24 (12.26 to 37.28)	< 0.001

Results are from a multivariable analysis; unadjusted: performed with one covariate at a time; adjusted: performed with all listed covariates included simultaneously. CCI Charlson Comorbidity Index, classified as 0, 1, or 2 +