Table 3.

Non-coding RNAs regulating autophagy in prostate cancer

Non-coding RNA	Signaling network	Effect on autophagy	Remarks	Refs
MIR124 MIR144	PIM1, autophagy	Inhibition	Hypoxia provides downregulation of MIR124 and MIR144 via disrupting DICER1 expression. Enhancing miRNA expression inhibits autophagy via PIM1 downregulation, leading to enhanced radio-sensitivity of prostate cancer cells.	[299]
MIR301A/B	NDRG2, autophagy	Induction	Increased expression of MIR301A/B in the presence of hypoxia. Binding to 3′-UTR of NDRG2 and reducing its expression. Autophagy induction and enhancing prostate cancer cell viability.	[300]
MIR96	MTOR, autophagy ATG7, autophagy	Induction Inhibition	Dual role of MIR96 in prostate cancer cells and autophagy regulation during hypoxia. Autophagy induction via inhibiting MTOR signaling. Autophagy inhibition via ATG7 downregulation.	[301]
MIR205	RAB27A LAMP3	Inhibition	Downregulation of RAB27A and LAMP3 in autophagy inhibition. Impairing proliferation and enhancing chemosensitivity of prostate cancer cells.	[302]
MIR34A	AMPK-MTOR-ATG4B	Inhibition	Reducing AMPK phosphorylation. Inducing MTOR signaling. Autophagy inhibition via ATG4B downregulation. Enhancing prostate cancer progression and reducing chemosensitivity.	[303]
LncRNA SNHG12	MIR195-CCNE1	Inhibition	Overexpression of SNHG12 in prostate cancer cells. Association with poor prognosis. Reducing MIR195 expression via sponging. Activation of PI3K-AKT-MTOR signaling. Reducing apoptosis and autophagy.	[304]
LncRNA PRRT3-AS1	PPPARG, autophagy	Inhibition	PARP downregulation in impairing autophagy. Enhancing proliferation of prostate cancer cells and reducing apoptosis.	[288]
Circ-CCNB2	MIR30B-5p-KIF18A	Induction	Reducing MIR30B-5p expression via sponging. Enhancing KIF18A expression. Autophagy induction and subsequent resistance to radiation therapy.	[298]