Fig. 1.

Schematic representation for the human medical diagnosis of alcohol use disorder (AUD) in relation to different animal models used in biomedical research. An AUD diagnosis encapsulates many different phenotypic traits (e.g., ‘craving’ and ‘withdrawal’). Genome-wide studies of model organisms that address latent features of AUD can help decipher coordinated biological activity of interrelated modules found in humans (colored blocks along y-axis).