| Methods |
Randomised clinical trial. |
| Participants |
Country: USA.
Sample size: 30.
Post‐randomisation drop‐out(s): not stated.
Revised sample size: 30.
Females: not stated.
Mean age: 49.5 years.
Piggyback: not stated.
Conventional: not stated.
Cadaveric donor: not stated.
Live donor: not stated.
Inclusion criteria:
1. Patients undergoing orthotopic liver transplantation.
2. Age more than 18 years.
3. Patients having a reaction time (R‐time) more than 15 minutes.
Exclusion criteria:
1. Patients already taking oestrogen therapy.
2. Received blood products in preparation for surgery.
3. Patients undergoing retransplantation. |
| Interventions |
The patients were randomised to the following groups.
Group 1: intervention (n = 15).
Further details: conjugated oestrogen 100 mg intravenous when the reaction time was longer than 15 minutes at the beginning of surgery and 30 minutes after reperfusion of the new graft.
Group 2: control (n = 15).
Further details: placebo (equal volume of normal saline). |
| Outcomes |
The outcomes reported were blood transfusion requirements. |
| Notes |
Attempts were made to contact the author in September 2011. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Quote: "Study drugs were prepared by the hospital pharmacy using a randomisation schedule; all other personnel were blinded to the randomisation. The researchers were informed about the contents of the blinded syringes after the study". |
| Allocation concealment (selection bias) |
Low risk |
Quote: "Study drugs were prepared by the hospital pharmacy using a randomisation schedule; all other personnel were blinded to the randomisation. The researchers were informed about the contents of the blinded syringes after the study". |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Quote: "Study drugs were prepared by the hospital pharmacy using a randomisation schedule; all other personnel were blinded to the randomisation. The researchers were informed about the contents of the blinded syringes after the study". |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
Quote: "Study drugs were prepared by the hospital pharmacy using a randomisation schedule; all other personnel were blinded to the randomisation. The researchers were informed about the contents of the blinded syringes after the study". |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
Comment: This information was not available. |
| Selective reporting (reporting bias) |
High risk |
Comment: Important outcomes were not reported. |
| Vested interest bias |
Unclear risk |
Comment: This information was not available. |
