Pugliese 2007.

Methods	Randomised clinical trial.
Participants	Country: Italy. Sample size: 20. Post‐randomisation drop‐out(s): not stated. Revised sample size: 20. Females: not stated. Mean age: not stated. Piggyback: not stated. Conventional: not stated. Cadaveric donor: not stated. Live donor: not stated. Inclusion criteria: 1. Patients undergoing orthotopic liver transplantation.
Interventions	The patients were randomised to the following groups. Group 1: intervention (n = 10). Further details: rFVIIa 40 mcg/kg as bolus immediately before anaesthesia induction. Group 2: control (n = 10). Further details: placebo (details not known).
Outcomes	The outcomes reported were mortality, primary graft non‐function, ITU stay, and blood transfusion requirements (the transfusion requirements during the entire operation and immediate post‐operative period was not reported and so this information could not be used).
Notes	Attempts were made to contact the authors in September 2011.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: This information was not available.
Allocation concealment (selection bias)	Unclear risk	Comment: This information was not available.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Comment: Although the authors state that a placebo was used, they do not state the nature of the placebo or the groups who knew whether the test drug was rFVIIa or placebo.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Comment: Although the authors state that a placebo was used, they do not state the nature of the placebo or the groups who knew whether the test drug was rFVIIa or placebo.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Comment: This information was not available.
Selective reporting (reporting bias)	High risk	Comment: Important outcomes were not reported.
Vested interest bias	Unclear risk	Comment: This information was not available.