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. Author manuscript; available in PMC: 2022 Mar 22.
Published in final edited form as: Int Rev Neurobiol. 2020 Oct 14;156:63–86. doi: 10.1016/bs.irn.2020.08.006

Fig. 1.

Fig. 1

Overview of potential biochemical processes involved in epigenomic regulation of cellular function for the neuropathology of disease. The molecular phenotypes of individual cells in the central nervous system (i.e., neurons, astrocytes, microglia, and oligodendrocytes) are influenced by the continual interaction of single nucleotide variation in DNA and epigenetic regulation. DNA is condensed into chromatin through the association with histone proteins. Post-translational modification of histones may occur through ubiquitination (Ub), acetylation (Ac), mono- (Me1), di- (Me2), and tri-methylation (Me3). The regulation of mRNA and proteins may also be regulated by non-coding RNA transcripts including microRNAs, circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs).